Howe's side - who are in the Carabao Cup final for the second time in three years - will now play either Tottenham or Liverpool in the showpiece event on Sunday, March 16.
Isak, who has repeatedly been linked with the Gunners in recent months, impressed against the visitor's defence duo of Gabriel Magalhaes and William Saliba during the semi-final.
Jamie Carragher has named an increasingly common move that he believes should be 'banned' in the wake of Newcastle's second goal in their Carabao Cup semi-final against Arsenal.
On the heels of a January transfer window that saw Arteta fail to add attacking firepower to his squad, Neville offered a brutal assessment of the north London side's fatal flaws on the night.
The 31-year-old, who previously had a loan spell with the Turkish club, departs Molineux following two years after signing an 18-month contract in Istanbul with the option of an extra year.